Publications PMM

La Plateforme Métabolisme-Métabolome de l'IPS2


  • Yuan Shen, Tingting Lei1, Xiaoyun Cui, Xiaoyun Liu, Shaoli Zhou, Yu Zheng, Florence Guérard, Emmanuelle Issakidis-Bourguet and Dao-Xiu Zhou Arabidopsis histone deacetylase HDA15 directly represses plant response to elevated ambient temperature. doi: 10.1111/tpj.14492 The Plant Journal (2019) 100, 991–1006.
  • Rachid Jellali, Stephane Poulain, Myriam Lereau Bernier, Françoise Gilard, Yannick Tauran, Sachi Kato, Mathieu Danoy, Bertrand David Segard, Taketomo Kido, Atsushi Miyajima, Charles Plessy, Yasuyuki Sakai, Eric Leclerc: Integration of metabolomic and transcriptomic profiling to compare two protocols of differentiation of human induced pluripotent stem cells into hepatocytes. DOI:10.1016/j.procbio.2019.09.034
  • Cathleen Mirande-ney, Guillaume Tcherkez, Francoise Gilard, Jaleh Ghashghaie, Emmanuelle Lamade: Potassium fertilization affects oil palm fruit metabolism but has little effect on mesocarp lipid accumulation. Journal of Agricultural and Food Chemistry 08/2019; 67(33)., DOI:10.1021/acs.jafc.9b04336
  • Liu Y, Mauve C, Lamothe-Sibold M, Guérard F, Glab N, Hodges M, Jossier M. (2019)Photorespiratory serine hydroxymethyltransferase 1 activity impacts abiotic stress tolerance and stomatal closure. Plant , Cell and Environment. DOI: 10.1111/pce.13595

  • Molero, G. Tcherkez, G. Roca, R. Mauve, C. Cabrera-Bosquet, L. Araus, J.L. Nogue´s, S. Aranjuelo, I.(2019) Do metabolic changes underpin physiological responses to water limitation in alfalfa (Medicago sativa) plants during a regrowth period? Molero and al. Agricultural Water Management Volume 212, 1 February 2019, Pages 1-11. DOI: 10.1016/j.agwat.2018.08.021

  • Florian Lamouche, Anaïs Chaumeret, Ibtissem Guefrachi, Quentin Barrière, Olivier Pierre, Florence Guérard, Françoise Gilard, Eric Giraud, Yves DESSAUX, Bertrand Gakière, Tatiana Timchenko, Attila Kereszt, Peter Mergaert, and Benoit Alunni (2019) From intracellular bacteria to differentiated bacteroids: transcriptome and metabolome analysis in Aeschynomene nodules using the Bradyrhizobium sp. ORS285 bclA mutant. Journal of Bacterioloy. DOI: 10.1128/JB.00191-19

  • Maharajah Ponnaiah, Françoise Gilard, Bertrand Gakière, Hayat El-Maarouf-Bouteau, Christophe Bailly. (2019) Regulatory actors and alternative routes for Arabidopsis seed germination are revealed using a pathway-based analysis of transcriptomic datasets. The Plant Journal 03/2019;, DOI:10.1111/tpj.14311

  • Félix Lallemand, Marie-Laure Martin-Magniette, Françoise Gilard, Bertrand Gakière, Alexandra Launay-Avon, Étienne Delannoy, Marc-André Selosse. (2019) In situ transcriptomic and metabolomic study of the loss of photosynthesis in the leaves of mixotrophic plants exploiting fungi. The Plant Journal 02/2019; 98(5)., DOI:10.1111/tpj.14276



  • M. Gatti, F. Cambon, C. Tassy, C. Macadre, F. Guerard, T. Langin, M. Dufresne (2018). The Brachypodium distachyon UGT Bradi5gUGT03300 confers type II fusarium head blight resistance in wheat. Plant Pathologie. DOI:

  • Miriam Gatti, Frédéric Choulet, Catherine Macadré, Florence Guérard, Jean-Marc Seng, Thierry Langin, Marie Dufresne. (2018) Identification, Molecular Cloning, and Functional Characterization of a Wheat UDP-Glucosyltransferase Involved in Resistance to Fusarium Head Blight and to Mycotoxin Accumulation. Frontiers in Plant Science. , Vol 9 (2018) DOI: 10.3389/fpls.2018.01853

  • Qiong Xia, Marine Saux, Maharajah Ponnaiah, Françoise Gilard, François Perreau, Stéphanie Huguet, Sandrine Balzergue, Nicolas Langlade, Christophe Bailly, Patrice Meimoun, Françoise Corbineau and Hayat El-Maarouf-Bouteau..(2018).  One Way to Achieve Germination: Common Molecular Mechanism Induced by Ethylene and After-Ripening in Sunflower Seeds. Int. J. Mol. Sci. 2018, 19, 2464. doi: 10.3390/ijms19082464.

  • Rachid Jellali, Françoise Gilard, Vittoria Pandolfi, Audrey Legendre, Marie‐José Fleury, Patrick Paullier, Cécile Legallais, Eric Leclerc. (2018) Metabolomics‐on‐a‐chip approach to study hepatotoxicity of DDT, permethrin and their mixtures. Wiley Online Library. DOI: 10.1002/jat.3624

  • Rachid Jellali, Françoise Gilard, Vittoria Pandolfi, Audrey Legendre, Marie-José Fleury, Patrick Paullier, Cécile Legallais, Eric Leclerc. (2018) Metabolomics-on-a-chip approach to study hepatotoxicity of DDT, permethrin and their mixtures. Journal of Applied Toxicology 04/2018; 38(8)., DOI:10.1002/jat.3624

  • Rachid Jellali, Perrine Zeller, Françoise Gilard, Audrey Legendre, Marie José Fleury, Sébastien Jacques, Guillaume Tcherkez, Eric Leclerc. (2018)  Effects of DDT and permethrin on rat hepatocytes cultivated in microfluidic biochips: metabolomics and gene expression study. Environmental Toxicology and Pharmacology. DOI: 10.1016/j.etap.2018.02.004.

  • Lauriane Cabon, Audrey Bertaux, Marie-Noëlle Brunelle-Navas, Ivan Nemazanyy, Laurianne Scourzic, Laure Delavallée, Laura Vela, Mathieu Baritaud, Sandrine Bouchet, Cécile Lopez, Vu Quang Van, Kevin Garbin, Danielle Chateau, Françoise Gilard, Marika Sarfati, Thomas Mercher, Olivier A. Bernard, Santos A. Susin. (2018) AIF loss deregulates hematopoiesis and reveals different adaptive metabolic responses in bone marrow cells and thymocytes. Cell Death and Differentiation. DOI:10.1038/s41418-017-0035-x.


  • Soumaya Khlifi, Caroline Mauve, Nathalie Glab, Francoise Gilard, Michael Hodges, Gregory Mouille, Jonathan Farjon. (2017) An easier analysis of complex mixtures with highly resolved and sensitivity enhanced 2D quantitative NMR: application to tracking sugar phosphates in plants. Analytical methods 04/2017; 9(15)., DOI:10.1039/C7AY00316A.

  • Baptiste Genot, Julien Lang, Souha Berriri, Marie Garmier, Françoise Gilard, Stéphanie Pateyron, Katrien Haustraete, Dominique Van Der Straeten, Heribert Hirt, Jean Colcombet: Constitutively Active Arabidopsis MAP Kinase 3 Triggers Defense Responses Involving Salicylic Acid and SUMM2 Resistance Protein. (2017) Plant physiology 04/2017; 174(2):pp.00378.2017., DOI:10.1104/pp.17.00378.

  • Liziane Cristina Brusamarello-Santos, Françoise Gilard, Lenaïg Brulé, Isabelle Quilleré, Benjamin Gourion, Pascal Ratet, Emanuel Maltempi de Souza, Peter J. Lea, Bertrand Hirel:. (2017) Metabolic profiling of two maize (Zea mays L.) inbred lines inoculated with the nitrogen fixing plant-interacting bacteria Herbaspirillum seropedicae and Azospirillum brasilense. PLoS ONE 03/2017; 12(3)., DOI:10.1371/journal.pone.0174576.


  • Pétriacq P, De Bont P, Genestout L, Hao J, Laureau C, Florez-Sarasa I, Rzigui T, Queval G, Gilard F, Mauve C, Guérard F, Lamothe-Sibold M, Marion J, Fresneau C, Brown S, Danon A, Krieger-Liszkay A, Berthomé R, Ribas-Carbo M, Tcherkez G, Cornic G, Pineau B, Gakiere B, De Paepe R (2016). Photoperiod Affects the Phenotype of Mitochondrial Complex I Mutants. Plant Physiology, pp.01484.2016; DOI: 10.1104/pp.16.01484.

  • Illa Tea, Estelle Martineau, Ingrid Antheaume, Julie Lalande, Caroline Mauve, Francoise Gilard, Sophie Barillé-Nion, Anneke C. Blackburn, Guillaume Tcherkez. (2016) 13C and 15N natural isotope abundance reflects breast cancer cell metabolism. Scientific Reports 09/2016; 6., DOI:10.1038/srep34251.

  • Abadie C, Lamothe-Sibold M, Gilard F, Tcherkez G. (2016) Isotopic evidence for nitrogen exchange between autotrophic and heterotrophic tissues in variegated leaves. Funct Plant Biol, 43, 298-306.

  • P. Zeller, A. Legendre, S. Jacques, M.J. Fleury, F. Gilard, G. Tcherkez, E. Leclerc. (2016) Hepatocytes cocultured with Sertoli cells in bioreactor favors Sertoli barrier tightness in rat. Journal of Applied Toxicology 07/2016; 37(3)., DOI:10.1002/jat.3360

  • Fan Su, Françoise Gilard, Florence Guérard, Sylvie Citerne, Christophe Clément, Nathalie Vaillant-Gaveau, Sandrine Dhondt-Cordelier. (2016) Spatio-temporal Responses of Arabidopsis Leaves in Photosynthetic Performance and Metabolite Contents to Burkholderia Phytofirmans PsJN. Frontiers in Plant Science 04/2016; 7(256)., DOI:10.3389/fpls.2016.00403.

  • Caroline Mauve, Soumaya Khlifi, Françoise Gilard, Grégory Mouille, Jonathan Farjon. (2016) Sensitive, highly resolved, and quantitative (1)H-(13)C NMR data in one go for tracking metabolites in vegetal extracts. Chemical Communications 04/2016; 52(36)., DOI:10.1039/c6cc01783e

  • Abadie C, Lamothe M, Mauve C, Gilard F, Tcherkez G. (2015) Leaf green-white variegation is advantageous under N deprivation in Pelargonium × hortorum. Funct Plant Biol, 42, 543-551.

  • Mihoub I, Ghashghaie J, Badeck F-W, Robert T, Lamothe-Sibold M, Fatiha A. (2016). Intraspecific variability of carbon isotope discrimination and its correlation with grain yield in safflower : prospects for selection in a Mediterranean climate. Isotopes in Environmental and Health Studies. 52. 1-15


  • Rogowsky P, Grimault A, Gendrot G, Chaignon S, Gilard F, Tcherkez G, Thévenin J, Dubreucq B, Depège-Fargeix N. (2015) Role of B3 domain transcription factors of the AFL family in maize kernel filling. Plant Sci 236 : 116–125.

  • Aranjuelo I, Tcherkez G, Jauregui I, Gilard F, Ancín M, Fernández-San Millán A, Larraya L, Veramendi J, Farran J. (2015) Alteration by thioredoxin f over-expression of primary carbon metabolism and its response to elevated CO2 in tobacco. DOI: 10.1016/j.envexpbot. 2015.05.008,  (Nicotiana tabacum L.), Environmental and Experimental Botany, Volume 118, October 2015, Pages 40-48, ISSN 0098-8472.

  • Dellero Y, Lamothe-Sibold M, Jossier M, Hodges M. (2015) Arabidopsis thaliana ggt1 photorespiratory mutants maintain leaf carbon:nitrogen balance by reducing RuBisCO content and plant growth. Plant J. 2015 Jul 28. DOI : 10.1111/tpj.12945.

  • Lamade E, Tcherkez G, Darlan NH, Rodrigues RL, Fresneau C, Mauve C, Lamothe-Sibold M, Sketriené D, Ghashghaie J. (2015) Natural 13C distribution in oil palm (Elaeis guineensis Jacq.) and consequences for allocation pattern. Plant Cell Environ. 2015 Jul 29. doi : 10.1111/pce.12606.

  • Aranjuelo I, Erice G, Sanz-Sáez A, Abadie C, Gilard F, Gil-Quintana E, Avice JC, Staudinger C, Wienkoop S, Araus JL, Bourguignon J, Irigoyen JJ, Tcherkez G. (2015) Differential CO2 effect on primary carbon metabolism of flag leaves in durum wheat (Triticum durum Desf.). Plant Cell Environ. 2015 Jun 17. DOI : 10.1111/pce.12587.

  • Barzegar T., Delshad M., Kashi A.K., Mauve C, Ghashghaie J. (2015) Sugar accumulation pattern and contents in developing fruits of two Iranian melon cultivars.Iranian Journal of Plant Physiology. DOI:10.1016/j.plantsci.2015.07.023],5(3):1353-1359.

  • Sawicki M, Barka EA, Clément C, Gilard F, Tcherkez G, Baillieul F, Vaillant-Gaveau N, Jacquard C. (2015) Cold-night responses in grapevine inflorescences. Plant Science, Volume 239, October 2015, Pages 115-127, ISSN 0168-9452.

  • Ghashghaie J., Badeck FW., Girardin C., Sketriené D., Lamothe M., & Werner R.A. (2015) Changes in d13C of dark-respired CO2 and organic matter of different organs of peanut plants during early ontogeny.Isotopes in Environment and Health Studies,In press.

  • Mihoub I, Robert T, Ghashghaie J, Vilatersana R, LAMY F, Benmrid R, Lamothe-Sibold M, Fatiha A (2016). Phylogenetic position of two endemic Carthamus species in Algeria and their potential as sources of genes for water use efficiency improvement of safflower : Phylogeny of endemic Carthamus species in Algeria. Journal of Systematics and Evolution. 55. 10.1111/jse.12220.

  • Pitoux, D., Plainchont, B., Merlet, D., Hu, Z., Bonnaffé, D. Farjon, J., & Giraud, N. (2015) Fully Resolved NMR Correlation Spectroscopy Chemistry –A European Journal. 21, 25.


  • Guillaume Tcherkez, Florence Guérard, Françoise Gilard, Marlène Lamothe, Caroline Mauve, Elisabeth Gout, Richard Bligny. (2014) Corrigendum to: Metabolomic characterisation of the functional division of nitrogen metabolism in variegated leaves. Functional Plant Biology 01/2014; 41(3):330., DOI:10.1071/FP12189_CO

  • Mondy, S., Lenglet, A., Cosson, V., Pelletier, S., Pateyron, S., Gilard, F., Scholte, M., Brocard, L., Couzigou, J.M., Tcherkez, G., Pean, M., and Ratet, P. (2014). GOLLUM [FeFe]-hydrogenase-like proteins are essential for plant development in normoxic conditions and modulate energy metabolism. Plant Cell Environ 37, 54-69.

  • Dellero Y, Mauve C, Boex-Fontvieille E, Flesch V, Jossier M, Tcherkez G, Hodges M. (2014) Experimental evidence for a hydride transfer mechanism in plant glycolate oxidase catalysis. J Biol Chem, in press. doi : 10.1074/jbc.M114.618629

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