Publications

2024

  • The MKK3 module integrates nitrate and light signals to modulate secondary dormancy in Arabidopsis thaliana. Regnard S, Otani M, Keruzore M, Teinturier A, Blondel M, Kawakami N, Krapp A, Colcombet J. Proc Natl Acad Sci U S A. 2024 Oct;121(40):e2403646121. doi: 10.1073/pnas.2403646121. 

  • The MKK3 MAPK cascade integrates temperature and after-ripening signals to modulate seed germination. Otani M, Tojo R, Regnard S, Zheng L, Hoshi T, Ohmori S, Tachibana N, Sano T, Koshimizu S, Ichimura K, Colcombet J, Kawakami N. Proc Natl Acad Sci U S A,. 2024 Jul 9;121(28):e2404887121. doi: 10.1073/pnas.2404887121.

  • Integrated multi-omics and genetic analyses reveal molecular determinants underlying Arabidopsis snap33 mutant phenotype. Henchiri H, Rayapuram N, Alhoraibi HM, Caïus J, Paysant-Le Roux C, Citerne S, Hirt H, Colcombet J, Sturbois B, Bigeard J. Plant Journal, doi: 10.1111/tpj.16647.

2023

  •  Cell specialization and coordination in Arabidopsis leaves upon pathogenic attack revealed by scRNA-seq. Delannoy E, Batardiere B, Pateyron S, Soubigou-Taconnat L, Chiquet J, Colcombet J, Lang J. Plant Communications, , 100676, https://dx.doi.org/10.1016/j.xplc.2023.100676, https://hal.inrae.fr/hal-04194719

  • Pathogen-induced m6A dynamics affect plant immunity. Prall W, Sheikh AH, Bazin J, Bigeard J, Almeida-Trapp M, Crespi M, Hirt H, Gregory BD. Plant Cell. koad224, https://doi.org/10.1093/plcell/koad224

  • PlantACT! - how to tackle the climate crisis. Hirt H, Al-Babili S, Almeida-Trapp M, Martin A, Aranda M, Bartels D, Bennett M, Blilou I, Boer D, Boulouis A, Bowler C, Brunel-Muguet S, Chardon F, Colcombet J, Colot V, Daszkowska-Golec A, Dinneny JR, Field B, Froehlich K, Gardener CH, Gojon A, Gomès E, Gomez-Alvarez EM, Gutierrez C, Havaux M, Hayes S, Heard E, Hodges M, Alghamdi AK, Laplaze L, Lauersen KJ, Leonhardt N, Johnson X, Jones J, Kollist H, Kopriva S, Krapp A, Masson ML, McCabe MF, Merendino L, Molina A, Moreno Ramirez JL, Mueller-Roeber B, Nicolas M, Nir I, Orduna IO, Pardo JM, Reichheld JP, Rodriguez PL, Rouached H, Saad MM, Schlögelhofer P, Singh KA, De Smet I, Stanschewski C, Stra A, Tester M, Walsh C, Weber APM, Weigel D, Wigge P, Wrzaczek M, Wulff BBH, Young IM. Trends Plant Sci. 2023 May;28(5):537-543. doi: 10.1016/j.tplants.2023.01.005. Epub 2023 Feb 3. PMID: 36740490 Review.

  • Structural determinants of REMORIN nanodomain formation in anionic membranes Legrand A, G-Cava D, Jolivet MD, Decossas M, Lambert O, Bayle V, Jaillais Y, Loquet A, Germain V, Boudsocq M, Habenstein B, Vélez Tirado M, Mongrand S. Biophys J. 2023 Jun 6;122(11):2192-2202. doi:10.1016/j.bpj.2022.12.035. Epub 2022 Dec 28. PMID: 36582138

  • Essential role of the CD docking motif of MPK4 in plant immunity, growth, and development.Siodmak A, Shahul Hameed UF, Rayapuram N, Völz R, Boudsocq M, Alharbi S, Alhoraibi H, Lee YH, Blilou I, Arold ST, Hirt H. New Phytol. 2023 Aug;239(3):1112-1126. doi: 10.1111/nph.18989. Epub 2023 May 27. PMID: 37243525

2022

  • Abulfaraj AA, Alhoraibi HM, Mariappan K, Bigeard J, Zhang H, Almeida-Trapp M, Artyukh O, Abdulhakim F, Parween S, Pflieger D, Blilou I, Hirt H, Rayapuram N (2022) Analysis of the Arabidopsis coilin mutant reveals a positive role of AtCOILIN in plant immunity. Plant Physiol. 2022 Jun 8;kiac280.doi: 10.1093/plphys/kiac280.

  • Wang R, Himschoot E, Chen J, Boudsocq M, Geelen D, Friml J, Beeckman T and Vanneste S (2022) Constitutive active CPK30 interferes with root growth and endomembrane trafficking in Arabidopsis. Frontiers in Plant Sci, 13:862398

  • Yip Delormel T, Avila-Ospina L, Davanture M, Zivy M, Lang J, Valentin N, Rayapuram N, Hirt H, Colcombet J, Boudsocq M (2022) In vivo identification of putative CPK5 substrates in Arabidopsis thaliana. Plant Science. 314:111121

2021

  • Lang J, Genot B, Bigeard J, Colcombet J (2021) MAP Kinases 3 and 6 control Salicylic Acid signaling by upregulating NLR receptors during Pattern- and Effector-Triggered Immunity. J Exp Bot. 2022 Apr 5;73(7):2190-2205. doi: 10.1093/jxb/erab544

  • Rolli E, de Zélicourt A, Alzubaidy H, Karampelias M, Parween S, Rayapuram N, Han B, Froehlich K, Abulfaraj A, Alhoraibi H, Mariappan K, Andrés-Barrao C, Colcombet J, Hirt H (2021) The Lys-motif receptor LYK4 mediates Enterobacter sp. SA187 triggered salt tolerance in Arabidopsis thaliana. Environ Microbiol. Sous press

  • Gouguet P, Gronnier J, Legrand A, Perraki A, Jolivet MD, Deroubaix AF, German-Retana S, Boudsocq M, Habenstein B, Mongrand S, Germain V. (2021) Connecting the dots: from nanodomains to physiological functions of REMORINs. Plant Physiol. 185(3):632-649

  • Rayapuram N, Jarad M, Alhoraibi HM, Bigeard J, Abulfaraj AA, Völz R, Mariappan KG, Almeida-Trapp M, Schlöffel M, Lastrucci E, Bonhomme L, Gust AA, Mithöfer A, Arold ST, Pflieger D, Hirt H. (2021) Chromatin phosphoproteomics unravels a function for AT-hook motif nuclear localized protein AHL13 in PAMP-triggered immunity. Proc Natl Acad Sci U S A. 118(3):e2004670118

2020

  • Lang J, Colcombet J (2020) Sustained incompatibility between MAPK signaling and pathogen effectors. Int J Mol Sci.21(21):7954. doi: 10.3390/ijms21217954.

  • Sözen C, Schenk S, Boudsocq M, Chardin C, Almeida-Trapp M, Krapp A, Hirt H, Mithöfer A, Colcombet J (2020) Wounding and insect feeding trigger two independent MAPK pathways with distinct regulation and kinetics. Plant Cell. 32:1988

2019

  • Jiang Y, Han B, Zhang H, Mariappan KG, Bigeard J, Colcombet J, Hirt H. (2019) MAP4K4 associates with BIK1 to regulate plant innate immunity. EMBO Rep (2019)e47965

  • Yip Delormel T, Boudsocq M. (2019) Properties and functions of calcium-dependent protein kinases and their relatives in Arabidopsis thaliana. New Phytol. 2019 Aug 1. doi: 10.1111/nph.16088.

  • Zhang W, Cochet F, Ponnaiah M, Lebreton S, Matheron L, Pionneau C, Boudsocq M, Resentini F, Huguet S, Blázquez MÁ, Bailly C, Puyaubert J, Baudouin E. (2019) The MPK8-TCP14 pathway promotes seed germination in Arabidopsis. Plant J. 2019 Jul 20. doi: 10.1111/tpj.14461.

  • Ormancey M, Thuleau P, van der Hoorn RAL, Grat S, Testard A, Kamal KY, Boudsocq M, Cotelle V, Mazars C. (2019) Sphingolipid-induced cell death in Arabidopsis is negatively regulated by the papain-like cysteine protease RD21. Plant Sci. 2019 Mar;280:12-17. doi: 10.1016/j.plantsci.2018.10.028.

  • P Alhoraibi H, Bigeard J, Rayapuram N, Colcombet J, Hirt H (2019). Plant Immunity: The MTI-ETI Model and Beyond. Curr Issues Mol Biol. 30:39-58. doi: 10.21775/cimb.030.039. Epub 2018 Aug 2. Review

  • Vadovic, P., Samajova, O., Takac, T., Novák, D., Zapletalova, V., Colcombet, J., & Samaj, J. (2019). Biochemical and genetic interactions of phospholipase D alpha 1 and mitogen-activated protein kinase 3 affect Arabidopsis stress response. Frontiers in plant science, 10, 275.

2018

  • Perraki A, Gronnier J, Gouguet P, Boudsocq M, Deroubaix AF, Simon V, German-Retana S, Legrand A, Habenstein B, Zipfel C, Bayer E, Mongrand S, Germain V. (2018) REM1.3's phospho-status defines its plasma membrane nanodomain organization and activity in restricting PVX cell-to-cell movement. PLoS Pathog. 2018 Nov 12;14(11):e1007378. doi: 10.1371/journal.ppat.1007378.

  • Völz R, Kim S-K, Mi J, Mariappan KG, Guo X, Bigeard J, et al. (2018) The Trihelix transcription factor GT2-like 1 (GTL1) promotes salicylic acid metabolism, and regulates bacterial-triggered immunity. PLoS Genet 14(10): e1007708.

  • Abulfaraj A, Mariappan K, Bigeard J, Manickam P, Blilou I, Guo X, Al-Babili S, Pflieger D, Hirt H, Rayapuram N. The Arabidopsis homolog of human G3BP1 is a key regulator of stomatal and apoplastic immunity. Life Science Alliance (2018).

  • de Zélicourt A, Synek L, Saad MM, Alzubaidy H, Jalal R, Xie Y, Andrés-Barrao C, Rolli E, Guerard F, Mariappan KG, Daur I, Colcombet J, Benhamed M, Depaepe T, Van Der Straeten D, Hirt H. Ethylene induced plant stress tolerance by Enterobacter sp. SA187 is mediated by 2-keto-4-methylthiobutyric acid production. PLoS Genet. 2018 Mar 19;14(3):e1007273.

  • Bigeard J and Hirt H. Nuclear Signaling of Plant MAPKs. Frontiers in Plant Science (2018) 9:469

  • Rayapuram N*, Bigeard J*, Alhoraibi H*, Bonhomme L, Hesse AM, Vinh J, Hirt H, Pflieger D. Quantitative Phosphoproteomic Analysis Reveals Shared and Specific Targets of Arabidopsis Mitogen-Activated Protein Kinases (MAPKs) MPK3, MPK4, and MPK6. Molecular & Cellular Proteomics 2018 Jan;17(1):61-80.

2017

  • Lang J, Genot B, Hirt H, Colcombet J. Constitutive activity of the Arabidopsis MAP Kinase 3 confers resistance to Pseudomonas syringae and drives robust immune responses. Plant Signal Behav. 2017 Aug 3;12(8):e1356533

  • Chardin C, Schenk ST, Hirt H, Colcombet J, Krapp A. Review: Mitogen-Activated Protein Kinases in nutritional signaling in Arabidopsis. Plant Sci. 2017 Jul;260:101-108

  • Latrasse D, Jégu T, Li H, de Zelicourt A, Raynaud C, Legras S, Gust A, Samajova O, Veluchamy A, Rayapuram N, Ramirez-Prado JS, Kulikova O, Colcombet J, Bigeard J, Genot B, Bisseling T, Benhamed M, Hirt H. MAPK-triggered chromatin reprogramming by histone deacetylase in plant innate immunity. Genome Biol. 2017 Jul 6;18(1):131.

  • Liu KH, Niu Y, Konishi M, Wu Y, Du H, Sun Chung H, Li L, Boudsocq M, McCormack M, Maekawa S, Ishida T, Zhang C, Shokat K, Yanagisawa S, Sheen J. Discovery of nitrate-CPK-NLP signalling in central nutrient-growth networks. Nature. 2017 May 18;545(7654):311-316.

  • Luo X, Xu N, Huang J, Gao F, Zou H, Boudsocq M, Coaker G, Liu J. A Lectin Receptor-Like Kinase Mediates Pattern-Triggered Salicylic Acid Signaling. Plant Physiol. 2017 Aug;174(4):2501-2514.L

  • Seybold H, Boudsocq M, Romeis T. CDPK Activation in PRR Signaling. Methods Mol Biol. 2017;1578:173-183.

  • Genot B, Lang J, Berriri S, Garmier M, Gilard F, Pateyron S, Haustraete K, Van Der Straeten D, Hirt H, Colcombet J. Constitutively Active Arabidopsis MAP Kinase 3 Triggers Defense Responses Involving Salicylic Acid and SUMM2 Resistance Protein. Plant Physiol. 2017 Jun;174(2):1238-1249.

2016

  • de Zelicourt A, Colcombet J, Hirt H. The Role of MAPK Modules and ABA during Abiotic Stress Signaling. Trends Plant Sci. 2016 Aug;21(8):677-85

  • Colcombet J, Sözen C, Hirt H. Convergence of Multiple MAP3Ks on MKK3 Identifies a Set of Novel Stress MAPK Modules. Front Plant Sci. 2016 Dec 22;7:1941.

2015

  • Boudsocq M, Danquah A, de Zélicourt A, Hirt H, Colcombet J. Plant MAPK cascades: Just rapid signaling modules? Plant Signal Behav. 2015;10(9):e1062197.

  • Guzel Deger A, Scherzer S, Nuhkat M, Kedzierska J, Kollist H, Brosché M, Unyayar S, Boudsocq M, Hedrich R, Roelfsema MR. uard cell SLAC1-type anion channels mediate flagellin-induced stomatal closure.  New Phytol. 2015 Oct;208(1):162-73

  • Bigeard J, Colcombet J, Hirt H. Signaling mechanisms in pattern-triggered immunity (PTI). Mol Plant. 2015 Apr;8(4):521-39.

  • Danquah A, de Zélicourt A, Boudsocq M, Neubauer J, Frei Dit Frey N, Leonhardt N, Pateyron S, Gwinner F, Tamby JP, Ortiz-Masia D, Marcote MJ, Hirt H, Colcombet J. Identification and characterization of an ABA-activated MAP kinase cascade in Arabidopsis thaliana. Plant J. 2015 Apr;82(2):232-44.

2014

  • Hudik E, Berriri S, Hirt H, Colcombet J. Identification of constitutively active AtMPK6 mutants using a functional screen in Saccharomyces cerevisiae. Methods Mol Biol. 2014;1171:67-77.

  • Bigeard J, Pflieger D, Colcombet J, Gérard L, Mireau H, Hirt H. Protein complexes characterization in Arabidopsis thaliana by tandem affinity purification coupled to mass spectrometry analysis. Methods Mol Biol. 2014;1171:237-50.

  • Rayapuram N, Bonhomme L, Bigeard J, Haddadou K, Przybylski C, Hirt H, Pflieger D. Identification of novel PAMP-triggered phosphorylation and dephosphorylation events in Arabidopsis thaliana by quantitative phosphoproteomic analysis. J Proteome Res. 2014 Apr 4;13(4):2137-51.

  • Ovečka M, Takáč T, Komis G, Vadovič P, Bekešová S, Doskočilová A, Šamajová V, Luptovčiak I, Samajová O, Schweighofer A, Meskiene I, Jonak C, Křenek P, Lichtscheidl I, Škultéty L, Hirt H, Šamaj J. Salt-induced subcellular kinase relocation and seedling susceptibility caused by overexpression of Medicago SIMKK in Arabidopsis. J Exp Bot. 2014 Jun;65(9):2335-50.

  • Zourelidou M, Absmanner B, Weller B, Barbosa IC, Willige BC, Fastner A, Streit V, Port SA, Colcombet J, de la Fuente van Bentem S, Hirt H, Kuster B, Schulze WX, Hammes UZ, Schwechheimer C. Auxin efflux by PIN-FORMED proteins is activated by two different protein kinases, D6 PROTEIN KINASE and PINOID. Elife. 2014 Jun 19;3.

  • Neumann C, Fraiture M, Hernàndez-Reyes C, Akum FN, Virlogeux-Payant I, Chen Y, Pateyron S, Colcombet J, Kogel KH, Hirt H, Brunner F, Schikora A. The Salmonella effector protein SpvC, a phosphothreonine lyase is functional in plant cells. Front Microbiol. 2014 Oct 17;5:548.

  • García AV, Hirt H. Salmonella enterica induces and subverts the plant immune system. Front Microbiol. 2014 Apr 4;5:141.

  • Bigeard J, Rayapuram N, Pflieger D, Hirt H. Phosphorylation-dependent regulation of plant chromatin and chromatin-associated proteins. Proteomics. 2014 Oct;14(19):2127-40.

  • Bigeard J, Rayapuram N, Bonhomme L, Hirt H, Pflieger D. Proteomic and phosphoproteomic analyses of chromatin-associated proteins from Arabidopsis thaliana. Proteomics. 2014 Oct;14(19):2141-55.

  • Garcia AV, Charrier A, Schikora A, Bigeard J, Pateyron S, de Tauzia-Moreau ML, Evrard A, Mithöfer A, Martin-Magniette ML, Virlogeux-Payant I, Hirt H. Salmonella enterica flagellin is recognized via FLS2 and activates PAMP-triggered immunity in Arabidopsis thaliana. Mol Plant. 2014 Apr;7(4):657-74.

  • Frei dit Frey N, Garcia AV, Bigeard J, Zaag R, Bueso E, Garmier M, Pateyron S, de Tauzia-Moreau ML, Brunaud V, Balzergue S, Colcombet J, Aubourg S, Martin-Magniette ML, Hirt H. Functional analysis of Arabidopsis immune-related MAPKs uncovers a role for MPK3 as negative regulator of inducible defences. Genome Biol. 2014 Jun 30;15(6):R87.

2013

  • Šamajová O, Plíhal O, Al-Yousif M, Hirt H, Šamaj J. Improvement of stress tolerance in plants by genetic manipulation of mitogen-activated protein kinases. Biotechnol Adv. 2013 Jan-Feb;31(1):118-28

  • de Zelicourt A, Al-Yousif M, Hirt H. Rhizosphere microbes as essential partners for plant stress tolerance. Mol Plant. 2013 Mar;6(2):242-5

  • Latrasse D, Jégu T, Meng PH, Mazubert C, Hudik E, Delarue M, Charon C, Crespi M, Hirt H, Raynaud C, Bergounioux C, Benhamed M. Dual function of MIPS1 as a metabolic enzyme and transcriptional regulator. Nucleic Acids Res. 2013 Mar 1;41(5):2907-17

  • Khan M, Rozhon W, Bigeard J, Pflieger D, Husar S, Pitzschke A, Teige M, Jonak C, Hirt H, Poppenberger B. Brassinosteroid-regulated GSK3/Shaggy-like kinases phosphorylate mitogen-activated protein (MAP) kinase kinases, which control stomata development in Arabidopsis thaliana. J Biol Chem. 2013 Mar 15;288(11):7519-27

  • Smeets K, Opdenakker K, Remans T, Forzani C, Hirt H, Vangronsveld J, Cuypers A. The role of the kinase OXI1 in cadmium- and copper-induced molecular responses in Arabidopsis thaliana. Plant Cell Environ. 2013 Jun;36(6):1228-38

  • Montillet JL, Hirt H. New checkpoints in stomatal defense. Trends Plant Sci. 2013 Jun;18(6):295-7

  • Danquah A, de Zelicourt A, Colcombet J, Hirt H. The role of ABA and MAPK signaling pathways in plant abiotic stress responses. Biotechnol Adv. 2013 Oct 1.

  • Montillet JL, Leonhardt N, Mondy S, Tranchimand S, Rumeau D, Boudsocq M, Garcia AV, Douki T, Bigeard J, Laurière C, Chevalier A, Castresana C, Hirt H. An abscisic acid-independent oxylipin pathway controls stomatal closure and immune defense in Arabidopsis. PLoS Biol. 2013;11(3):e1001513

  • Evrard A, Kumar M, Lecourieux D, Lucks J, von Koskull-Döring P, Hirt H. Regulation of the heat stress response in Arabidopsis by MPK6-targeted phosphorylation of the heat stress factor HsfA2. PeerJ. 2013 Apr 2;1:e59

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