Redox regulation of plant HDACs in response to climate change

Kick-off REPHARE project : Redox regulation of plant HDACs in response to climate change

Histone deacetylases (HDACs) are key epigenetic regulators but how their activity is regulated remains largely unknown. The ANR project REPHARE that just started (the kick-off meeting took place on 6 February 2020) is designed to study regulation of posttranslational modifications, subcellular localization, enzymatic activity and epigenetic function of Arabidopsis HDACs in response to cellular redox state changes under elevated ambient temperatures. This project coordinated by Dao-Xiu Zhou from IPS2 also involves LGDP (ReDAC team, Univ. Perpignan) combining expertise in plant epigenetics and redox modifications/regulations.

Working hypothesis of REPHARE project.

Elevated ambient temperatures alter cellular redox Balance (ROS / NOS) and regulators (such as TRX / GRX) leading to redox modification changes of HDACs to regulate gene expression and metabolic activity, thereby enhancing stress plant adaptation.