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4 PhD Thesis recently defended at IPS2

Xiaoyun CUI

Dynamics of histone modification in integration of metabolic activity and stress response

Chromatin enzymes require important metabolites as substrates or cofactors. However, little is known about metabolite fluctuations affecting chromatin modification gene expression in plants at high temperature. In this thesis, we first identified HDA15 as a direct repressor of plant response to high temperature. Then, we found that activity of histone demethylases (JMJ14 and JMJ15) was dependent on cytosolic isocitrate dehydrogenase to regulate gene expression programs of plant thermal response. The results highlight the interplay between metabolism, epigenetics and plant adaptation to high temperature.

November 22, 2019

Thesis supervisor Dao-Xiu ZHOU



Plastidial editosome: questions, pieces of answers and digressions

Pentatricopeptide repeat proteins (PPR) are modular proteins required for organellar gene expression. The main objective of this PhD thesis was to study how some PPR proteins work together to perform RNA editing, which consists in base modifications of a transcript sequence.

December 17, 2019

Thesis co-supervisors Claire Lurin/Wojciech Majeran



Characterization of two primary metabolism enzymes in Arabidopsis thaliana: phosphoglycerate mutase and phosphoglycolate phosphatase

Plants need to rapidly and effectively react to environmental abiotic and biotic stresses using various regulatory mechanisms. The proteins post-translational modification (PTMs) is one way to do so. My PhD work focused on the post-translational regulation of two primary metabolism enzymes, and the impact on Arabidopsis thaliana.

December 18, 2019

Thesis supervisor Nathalie Glab-Perret



Characterization of gene networks controlling fruit initiation in melon

Fruit setting is the development of the resting ovary into a young fruit that grows rapidly after fertilization. In melons, fruit initiation and the ability to produce parthenocarpic fruits were not described and were therefore studied in this thesis project. The novelty of this work is the characterization of fruit initiation in melons at the cytological and molecular level by analysis of the expression profiles of candidate genes involved in fruit setting and by global transcriptome analyses using RNAseq.

February 6, 2020

Thesis supervisor Adnane Boualem